Jerry, rumor has it that those later 45 Colt Model 25's had better chamber and throat dimensions, and your beautiful example seems to bear that out. I have an 1873 45 Colt clone that has rather large throat dimensions, and I have a couple of other tricks I am going to try before resorting to a cylinder swap for this one. I think the guys here have the right idea, a larger slug should help quite a bit. I have a Lee hollow-base, 295-grain minie that casts up @.453 or so that I am going to try, with a slower burning powder. I'm also going to whip up a custom sizing die that doesn't size the brass down so much, as these large-throated guns have rather generous chamber dimensions as well. All in all this should be a solution that will work fine for a gun that I don't shoot much. If a guy shoots several hundred or several thousand rounds a year, these solutions wouldn't be too appealing, but for a casual and occasional plinker like me they should get the job done.
lathesmith